Endocrine Abstracts

Background: People who have autoimmune atrophic gastritis commonly develop type 1 gNETs, but are also at increased risk of developing gastric adenocarcinoma. Type I gNET patients usually have multiple gastric polyps and have an excellent prognosis when the polyps measure.Method: Retrospective audit of type I gNET patients managed within Liverpool ENETS Centre of Excellence 2004–2018.Results: 86 patients (median age 67 years, 5...

Aim: Organoid cultures are a powerful model system for the study of cell biology and human disease. Manipulation of the composition of the culture medium has been used to promote cellular differentiation in gastric organoids to allow more accurate modelling of the mature epithelial cells present in the stomach. However, methods to promote the differentiation of neuroendocrine cells and specifically enterochromaffin-like (ECL)-cells within a gastric organoid system have not yet...

Background: Type III gastric neuroendocrine neoplasms (g-NEN) are usually lesions of higher grade and often associated with loco-regional and distant metastases. Guidelines recommend partial or total gastrectomy with local lymph node resection. Data for less-extensive resections are limited.Aim: To assess whether advanced endoscopic excision [Endoscopic Mucosal Resection (EMR) or Endoscopic Submucosal Dissection (ESD)] or localized surgical approach (wed...